Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression

BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1), a major regulator of the plasmin-based pericellular proteolytic cascade, is significantly increased in human arterial plaques contributing to vessel fibrosis, arteriosclerosis and thrombosis, particularly in the context of elevated tissue TGF-β1...

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Detalles Bibliográficos
Autores principales: Samarakoon, Rohan, Chitnis, Subhanir S., Higgins, Stephen P., Higgins, Craig E., Krepinsky, Joan C., Higgins, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145778/
https://www.ncbi.nlm.nih.gov/pubmed/21829547
http://dx.doi.org/10.1371/journal.pone.0022896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145778/
https://www.ncbi.nlm.nih.gov/pubmed/21829547
http://dx.doi.org/10.1371/journal.pone.0022896

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