Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

We present a molecular dissection of pause site-dependent transcriptional termination for mammalian RNA polymerase II (Pol II)-transcribed genes. We show that nascent transcripts form RNA/DNA hybrid structures (R-loops) behind elongating Pol II and are especially prevalent over G-rich pause sites po...

Descripción completa

Detalles Bibliográficos
Autores principales: Skourti-Stathaki, Konstantina, Proudfoot, Nicholas J., Gromak, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145960/
https://www.ncbi.nlm.nih.gov/pubmed/21700224
http://dx.doi.org/10.1016/j.molcel.2011.04.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145960/
https://www.ncbi.nlm.nih.gov/pubmed/21700224
http://dx.doi.org/10.1016/j.molcel.2011.04.026

Ejemplares similares