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Thermostabilisation of an Agonist-Bound Conformation of the Human Adenosine A(2A) Receptor
The adenosine A(2A) receptor (A(2A)R) is a G-protein-coupled receptor that plays a key role in transmembrane signalling mediated by the agonist adenosine. The structure of A(2A)R was determined recently in an antagonist-bound conformation, which was facilitated by the T4 lysozyme fusion in cytoplasm...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145977/ https://www.ncbi.nlm.nih.gov/pubmed/21501622 http://dx.doi.org/10.1016/j.jmb.2011.03.075 |