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The MEK-ERK pathway negatively regulates bim expression through the 3' UTR in sympathetic neurons

BACKGROUND: Apoptosis plays a critical role during neuronal development and disease. Developing sympathetic neurons depend on nerve growth factor (NGF) for survival during the late embryonic and early postnatal period and die by apoptosis in its absence. The proapoptotic BH3-only protein Bim increas...

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Detalles Bibliográficos
Autores principales: Hughes, Rosie, Gilley, Jonathan, Kristiansen, Mark, Ham, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146425/
https://www.ncbi.nlm.nih.gov/pubmed/21762482
http://dx.doi.org/10.1186/1471-2202-12-69