Cargando…

Multiple ATR-Chk1 Pathway Proteins Preferentially Associate with Checkpoint-Inducing DNA Substrates

The ATR-Chk1 DNA damage checkpoint pathway is a critical regulator of the cellular response to DNA damage and replication stress in human cells. The variety of environmental, chemotherapeutic, and carcinogenic agents that activate this signal transduction pathway do so primarily through the formatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yilmaz, Seçil, Sancar, Aziz, Kemp, Michael G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146532/ https://www.ncbi.nlm.nih.gov/pubmed/21829571 http://dx.doi.org/10.1371/journal.pone.0022986

Ejemplares similares

Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
por: Liu, Yiyong, et al.
Publicado: (2010)

Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA
por: Choi, Jun-Hyuk, et al.
Publicado: (2009)

From checkpoint to checkpoint: DNA damage ATR/Chk1 checkpoint signalling elicits PD-L1 immune checkpoint activation
por: Mouw, Kent W., et al.
Publicado: (2018)

Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression
por: Di Benedetto, Anna, et al.
Publicado: (2017)

Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy
por: Manic, Gwenola, et al.
Publicado: (2015)

RNF8 mediates NONO degradation following UV-induced DNA damage to properly terminate ATR-CHK1 checkpoint signaling
por: Deshar, Rakesh, et al.
Publicado: (2019)

Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer
por: Liu, Kang, et al.
Publicado: (2021)

Exploring the ATR-CHK1 pathway in the response of doxorubicin-induced DNA damages in acute lymphoblastic leukemia cells
por: Ghelli Luserna Di Rorà, Andrea, et al.
Publicado: (2021)

Tim–Tipin dysfunction creates an indispensible reliance on the ATR–Chk1 pathway for continued DNA synthesis
por: Smith, Kevin D., et al.
Publicado: (2009)

Targeting the ATR-CHK1 Axis in Cancer Therapy
por: Rundle, Stuart, et al.
Publicado: (2017)

Natural products targeting the ATR-CHK1 signaling pathway in cancer therapy
por: Ahmed, Salman, et al.
Publicado: (2022)

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication
por: Sørensen, Claus Storgaard, et al.
Publicado: (2012)

Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling
por: Yan, Shan, et al.
Publicado: (2006)

Involvement of Host ATR-CHK1 Pathway in Hepatitis B Virus Covalently Closed Circular DNA Formation
por: Luo, Jun, et al.
Publicado: (2020)

Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation
por: Shen, Tao, et al.
Publicado: (2018)

ATM/Chk2 and ATR/Chk1 Pathways Respond to DNA Damage Induced by Movento(®) 240SC and Envidor(®) 240SC Keto-Enol Insecticides in the Germarium of Drosophila melanogaster
por: González-Marín, Berenyce, et al.
Publicado: (2023)

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1
por: Blasius, Melanie, et al.
Publicado: (2011)

JAK Inhibition Prevents DNA Damage and Apoptosis in Testicular Ischemia-Reperfusion Injury via Modulation of the ATM/ATR/Chk Pathway
por: Khashab, Farah, et al.
Publicado: (2021)

Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation
por: Yu, Xinfang, et al.
Publicado: (2020)

Topoisomerase II-binding protein 1 promotes the progression of prostate cancer via ATR-CHK1 signaling pathway
por: Li, Kaiwen, et al.
Publicado: (2020)

An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication
por: Moiseeva, Tatiana N., et al.
Publicado: (2019)

APE1 assembles biomolecular condensates to promote the ATR–Chk1 DNA damage response in nucleolus
por: Li, Jia, et al.
Publicado: (2022)

ATR and a Chk1-Aurora B pathway coordinate postmitotic genome surveillance with cytokinetic abscission
por: Mackay, Douglas R., et al.
Publicado: (2015)

Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells
por: Chen, Sansan, et al.
Publicado: (2016)

Activation of ATR-Chk1 pathway facilitates EBV-mediated transformation of primary tonsillar B-cells
por: Mordasini, Vanessa, et al.
Publicado: (2016)

Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer
por: Gralewska, Patrycja, et al.
Publicado: (2020)

CXCL2-mediated ATR/CHK1 signaling pathway and platinum resistance in epithelial ovarian cancer
por: Nie, Sipei, et al.
Publicado: (2021)

The MRN complex maintains the biliary-derived hepatocytes in liver regeneration through ATR-Chk1 pathway
por: Song, Jingmei, et al.
Publicado: (2023)

The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G(2)-Checkpoint Activation in Cells Exposed to Ionizing Radiation
por: Luo, Daxian, et al.
Publicado: (2023)

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
por: Sanjiv, Kumar, et al.
Publicado: (2015)

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
por: Sanjiv, Kumar, et al.
Publicado: (2016)

Clinical Candidates Targeting the ATR–CHK1–WEE1 Axis in Cancer
por: Gorecki, Lukas, et al.
Publicado: (2021)

An ATM–Chk2–INCENP pathway activates the abscission checkpoint
por: Petsalaki, Eleni, et al.
Publicado: (2020)

ATR and Chk1 Suppress a Caspase-3–Dependent Apoptotic Response Following DNA Replication Stress
por: Myers, Katie, et al.
Publicado: (2009)

The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction
por: Katsura, Mari, et al.
Publicado: (2009)

APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells
por: Hossain, Md Akram, et al.
Publicado: (2021)

Inhibition of ATR-Chk1 signaling blocks DNA double-strand-break repair and induces cytoplasmic vacuolization in metastatic osteosarcoma
por: Li, Xiaoyang, et al.
Publicado: (2020)

Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress
por: Saini, Priyanka, et al.
Publicado: (2015)

The nucleolus stress response is coupled to an ATR-Chk1–mediated G2 arrest
por: Ma, Hanhui, et al.
Publicado: (2013)

Inactivation of PRIM1 Function Sensitizes Cancer Cells to ATR and CHK1 Inhibitors()
por: Job, Albert, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_q4v3fv1kab1lh3ufqns1vms6s4