Cargando…
Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice()
Despite numerous evidences for neurotoxicity of overexpressed α-synuclein, a protective function was suggested for endogenous α-synuclein and other members of the synuclein family. This protective role is most important for and evident in presynaptic terminals, where synucleins are normally accumula...
Autores principales: | Al-Wandi, Abdelmojib, Ninkina, Natalia, Millership, Steven, Williamson, Sally J.M., Jones, Paul A., Buchman, Vladimir L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146702/ https://www.ncbi.nlm.nih.gov/pubmed/19097673 http://dx.doi.org/10.1016/j.neurobiolaging.2008.11.001 |
Ejemplares similares
-
β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins
por: Ninkina, Natalia, et al.
Publicado: (2021) -
Combinational losses of synucleins reveal their differential requirements for compensating age-dependent alterations in motor behavior and dopamine metabolism
por: Connor-Robson, Natalie, et al.
Publicado: (2016) -
γ-synuclein is a novel player in the control of body lipid metabolism
por: Millership, Steven, et al.
Publicado: (2013) -
Modulation of α-synuclein expression in transgenic animals for modelling synucleinopathies — is the juice worth the squeeze?
por: Buchman, Vladimir L., et al.
Publicado: (2008) -
Lipid Classes and Fatty Acid Patterns are Altered in the Brain of γ-Synuclein Null Mutant Mice
por: Guschina, Irina, et al.
Publicado: (2010)