Nitrosative damage to free and zinc-bound cysteine thiols underlies nitric oxide toxicity in wild-type Borrelia burgdorferi

Borrelia burgdorferi encounters potentially harmful reactive nitrogen species (RNS) throughout its infective cycle. In this study, diethylamine NONOate (DEA/NO) was used to characterize the lethal effects of RNS on B. burgdorferi. RNS produce a variety of DNA lesions in a broad spectrum of microbial...

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Detalles Bibliográficos
Autores principales: Bourret, Travis J, Boylan, Julie A, Lawrence, Kevin A, Gherardini, Frank C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147059/
https://www.ncbi.nlm.nih.gov/pubmed/21564333
http://dx.doi.org/10.1111/j.1365-2958.2011.07691.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147059/
https://www.ncbi.nlm.nih.gov/pubmed/21564333
http://dx.doi.org/10.1111/j.1365-2958.2011.07691.x

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