A Prokaryotic S1P Lyase Degrades Extracellular S1P In Vitro and In Vivo: Implication for Treating Hyperproliferative Disorders

Sphingosine-1-phosphate (S1P) regulates a broad spectrum of fundamental cellular processes like proliferation, death, migration and cytokine production. Therefore, elevated levels of S1P may be causal to various pathologic conditions including cancer, fibrosis, inflammation, autoimmune diseases and...

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Detalles Bibliográficos
Autores principales: Huwiler, Andrea, Bourquin, Florence, Kotelevets, Nataliya, Pastukhov, Oleksandr, Capitani, Guido, Grütter, Markus G., Zangemeister-Wittke, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148216/
https://www.ncbi.nlm.nih.gov/pubmed/21829623
http://dx.doi.org/10.1371/journal.pone.0022436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148216/
https://www.ncbi.nlm.nih.gov/pubmed/21829623
http://dx.doi.org/10.1371/journal.pone.0022436

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