Simulating EGFR-ERK Signaling Control by Scaffold Proteins KSR and MP1 Reveals Differential Ligand-Sensitivity Co-Regulated by Cbl-CIN85 and Endophilin

ERK activation is enhanced by the scaffolding proteins KSR and MP1, localized near the cell membrane and late endosomes respectively, but little is known about their dynamic interplay. We develop here a mathematical model with ordinary differential equations to describe the dynamic activation of EGF...

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Detalles Bibliográficos
Autores principales: Huang, Lu, Pan, Catherine Qiurong, Li, Baowen, Tucker-Kellogg, Lisa, Tidor, Bruce, Chen, Yuzong, Low, Boon Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148240/
https://www.ncbi.nlm.nih.gov/pubmed/21829671
http://dx.doi.org/10.1371/journal.pone.0022933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148240/
https://www.ncbi.nlm.nih.gov/pubmed/21829671
http://dx.doi.org/10.1371/journal.pone.0022933

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