Sildenafil preserves diastolic relaxation after reduction by L-NAME and increases phosphodiesterase-5 in the intercalated discs of cardiac myocytes and arterioles

OBJECTIVES: We investigated the influence of sildenafil on cardiac contractility and diastolic relaxation and examined the distribution of phosphodiesterase-5 in the hearts of hypertensive rats that were treated with by NG-nitro-L-arginine methyl ester (L-NAME). METHODS: Male Wistar rats were treate...

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Detalles Bibliográficos
Autores principales: Ferreira-Melo, Silvia Elaine, Demacq, Caroline, Lacchini, Silvia, Krieger, José Eduardo, Irigoyen, Maria Cláudia, Moreno, Heitor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2011
Materias:
Basic Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148473/
https://www.ncbi.nlm.nih.gov/pubmed/21876983
http://dx.doi.org/10.1590/S1807-59322011000700022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148473/
https://www.ncbi.nlm.nih.gov/pubmed/21876983
http://dx.doi.org/10.1590/S1807-59322011000700022

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