Reversible exposure of hydrophobic residues on albumin as a novel strategy for formulation of nanodelivery vehicles for taxanes

BACKGROUND: We report herein a novel strategy for the preparation of protein-based nanode-livery vehicles for hydrophobic active pharmaceutical ingredients. METHODS: The procedure consisted of three steps, ie, exposure of hydrophobic residues of a protein to a pH-induced partial unfolding: interacti...

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Detalles Bibliográficos
Autores principales: Garro, AG, Beltramo, DM, Alasino, RV, Leonhard, V, Heredia, V, Bianco, ID
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148845/
https://www.ncbi.nlm.nih.gov/pubmed/21822381
http://dx.doi.org/10.2147/IJN.S19163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148845/
https://www.ncbi.nlm.nih.gov/pubmed/21822381
http://dx.doi.org/10.2147/IJN.S19163

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