Suppression of T(H)17 Differentiation and Autoimmunity by a Synthetic ROR Ligand

T helper cells that produce Interleukin-17 (IL-17) (T(H)17 cells) are a recently identified CD4(+) T-cell subset with characterized pathological roles in autoimmune diseases(1–3). The nuclear receptors retinoic acid receptor-related orphan receptors α and γt (RORα and RORγt) have indispensible roles...

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Detalles Bibliográficos
Autores principales: Solt, Laura A., Kumar, Naresh, Nuhant, Philippe, Wang, Yongjun, Lauer, Janelle L., Liu, Jin, Istrate, Monica A., Kamenecka, Theodore M., Roush, William R., Vidović, Dušica, Schürer, Stephan C., Xu, Jihong, Wagoner, Gail, Drew, Paul D., Griffin, Patrick R., Burris, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148894/
https://www.ncbi.nlm.nih.gov/pubmed/21499262
http://dx.doi.org/10.1038/nature10075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148894/
https://www.ncbi.nlm.nih.gov/pubmed/21499262
http://dx.doi.org/10.1038/nature10075

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