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Uncoordinated Loss of Chromatid Cohesion Is a Common Outcome of Extended Metaphase Arrest
Chromosome segregation requires coordinated separation of sister chromatids following biorientation of all chromosomes on the mitotic spindle. Chromatid separation at the metaphase-to-anaphase transition is accomplished by cleavage of the cohesin complex that holds chromatids together. Here we show...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149067/ https://www.ncbi.nlm.nih.gov/pubmed/21829677 http://dx.doi.org/10.1371/journal.pone.0022969 |