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Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

Intramembrane proteolysis governs many cellular control processes, but little is known about how intramembrane proteases are regulated. iRhoms are a conserved subfamily of proteins related to rhomboid intramembrane serine proteases that lack key catalytic residues. We have used a combination of gene...

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Detalles Bibliográficos
Autores principales: Zettl, Markus, Adrain, Colin, Strisovsky, Kvido, Lastun, Viorica, Freeman, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149277/
https://www.ncbi.nlm.nih.gov/pubmed/21439629
http://dx.doi.org/10.1016/j.cell.2011.02.047