Engineered Bivalent Ligands to Bias ErbB Receptor-mediated Signaling and Phenotypes

The ErbB receptor family is dysregulated in many cancers, and its therapeutic manipulation by targeted antibodies and kinase inhibitors has resulted in effective chemotherapies. However, many malignancies remain refractory to current interventions. We describe a new approach that directs ErbB recept...

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Detalles Bibliográficos
Autores principales: Jay, Steven M., Kurtagic, Elma, Alvarez, Luis M., de Picciotto, Seymour, Sanchez, Edgar, Hawkins, Jessica F., Prince, Robin N., Guerrero, Yadir, Treasure, Carolyn L., Lee, Richard T., Griffith, Linda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149363/
https://www.ncbi.nlm.nih.gov/pubmed/21622572
http://dx.doi.org/10.1074/jbc.M111.221093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149363/
https://www.ncbi.nlm.nih.gov/pubmed/21622572
http://dx.doi.org/10.1074/jbc.M111.221093

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