Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

BACKGROUND: Reactive microglia are associated with β-amyloid (Aβ) deposit and clearance in Alzhiemer's Disease (AD). Paradoxically, entocranial resident microglia fail to trigger an effective phagocytic response to clear Aβ deposits although they mainly exist in an "activated" state....

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Detalles Bibliográficos
Autores principales: Pan, Xiao-dong, Zhu, Yuan-gui, Lin, Nan, Zhang, Jing, Ye, Qin-yong, Huang, Hua-pin, Chen, Xiao-chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149591/
https://www.ncbi.nlm.nih.gov/pubmed/21718498
http://dx.doi.org/10.1186/1750-1326-6-45

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149591/
https://www.ncbi.nlm.nih.gov/pubmed/21718498
http://dx.doi.org/10.1186/1750-1326-6-45

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