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BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina

BACKGROUND: Naturally occurring apoptosis is a developmental process that shapes the retina by eliminating overproduced neurons. In the absence of the proapoptotic Bcl-2 family member BAX, developmental apoptosis in the retina is disrupted and extra neurons survive. It is unknown how BAX is activate...

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Detalles Bibliográficos
Autores principales: Harder, Jeffrey M, Libby, Richard T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149592/
https://www.ncbi.nlm.nih.gov/pubmed/21762490
http://dx.doi.org/10.1186/1750-1326-6-50