Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

Sclerostin is a potent inhibitor of bone formation which is down-regulated by mechanical loading. To investigate the mechanisms involved we subjected Saos2 human osteoblastic cells to short periods of dynamic strain and used quantitative reverse transcriptase polymerase chain reaction to compare the...

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Detalles Bibliográficos
Autores principales: Galea, Gabriel L., Sunters, Andrew, Meakin, Lee B., Zaman, Gul, Sugiyama, Toshihiro, Lanyon, Lance E., Price, Joanna S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149668/
https://www.ncbi.nlm.nih.gov/pubmed/21723865
http://dx.doi.org/10.1016/j.febslet.2011.06.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149668/
https://www.ncbi.nlm.nih.gov/pubmed/21723865
http://dx.doi.org/10.1016/j.febslet.2011.06.019

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