Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery

The thiazolidinediones (TZDs) are used in the treatment of diabetes mellitus type 2. Their canonical effects are mediated by activation of the peroxisome proliferator–activated receptor γ (PPARγ) transcription factor. In addition to effects mediated by gene activation, the TZDs cause acute, transcri...

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Detalles Bibliográficos
Autores principales: Rusinova, Radda, Herold, Karl F., Sanford, R. Lea, Greathouse, Denise V., Hemmings, Hugh C., Andersen, Olaf S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149818/
https://www.ncbi.nlm.nih.gov/pubmed/21788612
http://dx.doi.org/10.1085/jgp.201010529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149818/
https://www.ncbi.nlm.nih.gov/pubmed/21788612
http://dx.doi.org/10.1085/jgp.201010529

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