Abnormalities of Thymic Stroma may Contribute to Immune Dysregulation in Murine Models of Leaky Severe Combined Immunodeficiency

Lymphostromal cross-talk in the thymus is essential to allow generation of a diversified repertoire of T lymphocytes and to prevent autoimmunity by self-reactive T cells. Hypomorphic mutations in genes that control T cell development have been associated with immunodeficiency and immune dysregulatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Rucci, Francesca, Poliani, Pietro Luigi, Caraffi, Stefano, Paganini, Tiziana, Fontana, Elena, Giliani, Silvia, Alt, Frederick W., Notarangelo, Luigi Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150116/
https://www.ncbi.nlm.nih.gov/pubmed/21822418
http://dx.doi.org/10.3389/fimmu.2011.00015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150116/
https://www.ncbi.nlm.nih.gov/pubmed/21822418
http://dx.doi.org/10.3389/fimmu.2011.00015

Ejemplares similares