Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model

Peritoneal dialysis (PD) is associated with functional and structural changes of the peritoneal membrane. In this paper, we describe the impact of different factors contributing to peritoneal incompatibility of PD fluid installation including presence of a catheter, volume loading, and the PD fluid...

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Autores principales: Stavenuiter, Andrea W. D., Farhat, Karima, Schilte, Margot N., ter Wee, Piet M., Beelen, Robert H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150195/
https://www.ncbi.nlm.nih.gov/pubmed/21826269
http://dx.doi.org/10.4061/2011/742196
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author Stavenuiter, Andrea W. D.
Farhat, Karima
Schilte, Margot N.
ter Wee, Piet M.
Beelen, Robert H. J.
author_facet Stavenuiter, Andrea W. D.
Farhat, Karima
Schilte, Margot N.
ter Wee, Piet M.
Beelen, Robert H. J.
author_sort Stavenuiter, Andrea W. D.
collection PubMed
description Peritoneal dialysis (PD) is associated with functional and structural changes of the peritoneal membrane. In this paper, we describe the impact of different factors contributing to peritoneal incompatibility of PD fluid installation including presence of a catheter, volume loading, and the PD fluid components itself. These factors initiate recruitment and activation of peritoneal immune cells such as macrophages and mast cells, as well as activation of peritoneal cells as mesothelial cells in situ. We provide an overview of PD-associated changes as seen in our rat PD-exposure model. Since these changes are partly reversible, we finally discuss therapeutic strategies in the rat PD model with possible consequences of long-term PD in the relevant human setting.
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spelling pubmed-31501952011-08-08 Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model Stavenuiter, Andrea W. D. Farhat, Karima Schilte, Margot N. ter Wee, Piet M. Beelen, Robert H. J. Int J Nephrol Review Article Peritoneal dialysis (PD) is associated with functional and structural changes of the peritoneal membrane. In this paper, we describe the impact of different factors contributing to peritoneal incompatibility of PD fluid installation including presence of a catheter, volume loading, and the PD fluid components itself. These factors initiate recruitment and activation of peritoneal immune cells such as macrophages and mast cells, as well as activation of peritoneal cells as mesothelial cells in situ. We provide an overview of PD-associated changes as seen in our rat PD-exposure model. Since these changes are partly reversible, we finally discuss therapeutic strategies in the rat PD model with possible consequences of long-term PD in the relevant human setting. SAGE-Hindawi Access to Research 2011-08-02 /pmc/articles/PMC3150195/ /pubmed/21826269 http://dx.doi.org/10.4061/2011/742196 Text en Copyright © 2011 Andrea W. D. Stavenuiter et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Stavenuiter, Andrea W. D.
Farhat, Karima
Schilte, Margot N.
ter Wee, Piet M.
Beelen, Robert H. J.
Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model
title Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model
title_full Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model
title_fullStr Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model
title_full_unstemmed Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model
title_short Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model
title_sort bioincompatible impact of different peritoneal dialysis fluid components and therapeutic interventions as tested in a rat peritoneal dialysis model
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150195/
https://www.ncbi.nlm.nih.gov/pubmed/21826269
http://dx.doi.org/10.4061/2011/742196
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