Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model
Peritoneal dialysis (PD) is associated with functional and structural changes of the peritoneal membrane. In this paper, we describe the impact of different factors contributing to peritoneal incompatibility of PD fluid installation including presence of a catheter, volume loading, and the PD fluid...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150195/ https://www.ncbi.nlm.nih.gov/pubmed/21826269 http://dx.doi.org/10.4061/2011/742196 |
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author | Stavenuiter, Andrea W. D. Farhat, Karima Schilte, Margot N. ter Wee, Piet M. Beelen, Robert H. J. |
author_facet | Stavenuiter, Andrea W. D. Farhat, Karima Schilte, Margot N. ter Wee, Piet M. Beelen, Robert H. J. |
author_sort | Stavenuiter, Andrea W. D. |
collection | PubMed |
description | Peritoneal dialysis (PD) is associated with functional and structural changes of the peritoneal membrane. In this paper, we describe the impact of different factors contributing to peritoneal incompatibility of PD fluid installation including presence of a catheter, volume loading, and the PD fluid components itself. These factors initiate recruitment and activation of peritoneal immune cells such as macrophages and mast cells, as well as activation of peritoneal cells as mesothelial cells in situ. We provide an overview of PD-associated changes as seen in our rat PD-exposure model. Since these changes are partly reversible, we finally discuss therapeutic strategies in the rat PD model with possible consequences of long-term PD in the relevant human setting. |
format | Online Article Text |
id | pubmed-3150195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31501952011-08-08 Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model Stavenuiter, Andrea W. D. Farhat, Karima Schilte, Margot N. ter Wee, Piet M. Beelen, Robert H. J. Int J Nephrol Review Article Peritoneal dialysis (PD) is associated with functional and structural changes of the peritoneal membrane. In this paper, we describe the impact of different factors contributing to peritoneal incompatibility of PD fluid installation including presence of a catheter, volume loading, and the PD fluid components itself. These factors initiate recruitment and activation of peritoneal immune cells such as macrophages and mast cells, as well as activation of peritoneal cells as mesothelial cells in situ. We provide an overview of PD-associated changes as seen in our rat PD-exposure model. Since these changes are partly reversible, we finally discuss therapeutic strategies in the rat PD model with possible consequences of long-term PD in the relevant human setting. SAGE-Hindawi Access to Research 2011-08-02 /pmc/articles/PMC3150195/ /pubmed/21826269 http://dx.doi.org/10.4061/2011/742196 Text en Copyright © 2011 Andrea W. D. Stavenuiter et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Stavenuiter, Andrea W. D. Farhat, Karima Schilte, Margot N. ter Wee, Piet M. Beelen, Robert H. J. Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model |
title | Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model |
title_full | Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model |
title_fullStr | Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model |
title_full_unstemmed | Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model |
title_short | Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model |
title_sort | bioincompatible impact of different peritoneal dialysis fluid components and therapeutic interventions as tested in a rat peritoneal dialysis model |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150195/ https://www.ncbi.nlm.nih.gov/pubmed/21826269 http://dx.doi.org/10.4061/2011/742196 |
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