Enzyme Kinetics of the Mitochondrial Deoxyribonucleoside Salvage Pathway Are Not Sufficient to Support Rapid mtDNA Replication

Using a computational model, we simulated mitochondrial deoxynucleotide metabolism and mitochondrial DNA replication. Our results indicate that the output from the mitochondrial salvage enzymes alone is inadequate to support a mitochondrial DNA replication duration of as long as 10 hours. We find th...

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Detalles Bibliográficos
Autores principales: Gandhi, Vishal V., Samuels, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150320/
https://www.ncbi.nlm.nih.gov/pubmed/21829339
http://dx.doi.org/10.1371/journal.pcbi.1002078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150320/
https://www.ncbi.nlm.nih.gov/pubmed/21829339
http://dx.doi.org/10.1371/journal.pcbi.1002078

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