The Global DNA Methylation Surrogate LINE-1 Methylation Is Correlated with MGMT Promoter Methylation and Is a Better Prognostic Factor for Glioma

Gliomas are the most frequently occurring primary brain tumor in the central nervous system of adults. Glioblastoma multiformes (GBMs, WHO grade 4) have a dismal prognosis despite the use of the alkylating agent, temozolomide (TMZ), and even low grade gliomas (LGGs, WHO grade 2) eventually transform...

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Detalles Bibliográficos
Autores principales: Ohka, Fumiharu, Natsume, Atsushi, Motomura, Kazuya, Kishida, Yugo, Kondo, Yutaka, Abe, Tatsuya, Nakasu, Yoko, Namba, Hiroki, Wakai, Kenji, Fukui, Takashi, Momota, Hiroyuki, Iwami, Kenichiro, Kinjo, Sayano, Ito, Maki, Fujii, Masazumi, Wakabayashi, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150434/
https://www.ncbi.nlm.nih.gov/pubmed/21829728
http://dx.doi.org/10.1371/journal.pone.0023332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150434/
https://www.ncbi.nlm.nih.gov/pubmed/21829728
http://dx.doi.org/10.1371/journal.pone.0023332

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