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FUS and TARDBP but Not SOD1 Interact in Genetic Models of Amyotrophic Lateral Sclerosis

Mutations in the SOD1 and TARDBP genes have been commonly identified in Amyotrophic Lateral Sclerosis (ALS). Recently, mutations in the Fused in sarcoma gene (FUS) were identified in familial (FALS) ALS cases and sporadic (SALS) patients. Similarly to TDP-43 (coded by TARDBP gene), FUS is an RNA bin...

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Detalles Bibliográficos
Autores principales: Kabashi, Edor, Bercier, Valérie, Lissouba, Alexandra, Liao, Meijiang, Brustein, Edna, Rouleau, Guy A., Drapeau, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150442/
https://www.ncbi.nlm.nih.gov/pubmed/21829392
http://dx.doi.org/10.1371/journal.pgen.1002214