Purinergic Activation of Ca(2+)-Permeable TRPV4 Channels Is Essential for Mechano-Sensitivity in the Aldosterone-Sensitive Distal Nephron

Mechanical forces are known to induce increases of [Ca(2+)](i) in the aldosterone-sensitive distal nephron (ASDN) cells to regulate epithelial transport. At the same time, mechanical stress stimulates ATP release from ASDN cells. In this study, we combined ratiometric Fura-2 based monitoring of [Ca(...

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Detalles Bibliográficos
Autores principales: Mamenko, Mykola, Zaika, Oleg, Jin, Min, O'Neil, Roger G., Pochynyuk, Oleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151261/
https://www.ncbi.nlm.nih.gov/pubmed/21850238
http://dx.doi.org/10.1371/journal.pone.0022824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151261/
https://www.ncbi.nlm.nih.gov/pubmed/21850238
http://dx.doi.org/10.1371/journal.pone.0022824

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