Follicular regulatory T (Tfr) cells with dual Foxp3 and Bcl6 expression suppress germinal center reactions

Foxp3(+) regulatory T (T(reg)) cells suppress different types of immune responses to help maintain homeostasis in the body. How T(reg) cells regulate humoral immunity, including germinal center reactions, is unclear. Here we identify a subset of T(reg) cells expressing CXCR5 and Bcl6, and localized...

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Autores principales: Chung, Yeonseok, Tanaka, Shinya, Chu, Fuliang, Nurieva, Roza, Martinez, Gustavo J., Rawal, Seema, Wang, Yi-Hong, Lim, Ho Yong, Reynolds, Joseph M., Zhou, Xiao-hui, Fan, Hui-min, Liu, Zhong-ming, Neelapu, Sattva S., Dong, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151340/
https://www.ncbi.nlm.nih.gov/pubmed/21785430
http://dx.doi.org/10.1038/nm.2426
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author Chung, Yeonseok
Tanaka, Shinya
Chu, Fuliang
Nurieva, Roza
Martinez, Gustavo J.
Rawal, Seema
Wang, Yi-Hong
Lim, Ho Yong
Reynolds, Joseph M.
Zhou, Xiao-hui
Fan, Hui-min
Liu, Zhong-ming
Neelapu, Sattva S.
Dong, Chen
author_facet Chung, Yeonseok
Tanaka, Shinya
Chu, Fuliang
Nurieva, Roza
Martinez, Gustavo J.
Rawal, Seema
Wang, Yi-Hong
Lim, Ho Yong
Reynolds, Joseph M.
Zhou, Xiao-hui
Fan, Hui-min
Liu, Zhong-ming
Neelapu, Sattva S.
Dong, Chen
author_sort Chung, Yeonseok
collection PubMed
description Foxp3(+) regulatory T (T(reg)) cells suppress different types of immune responses to help maintain homeostasis in the body. How T(reg) cells regulate humoral immunity, including germinal center reactions, is unclear. Here we identify a subset of T(reg) cells expressing CXCR5 and Bcl6, and localized in the germinal centers in mouse as well as human. The expression of CXCR5 on T(reg) cells depends on Bcl6. These CXCR5(+)Bcl6(+) T(reg) cells are absent in thymus but can be de novo generated from CXCR5(-)Foxp3(+) natural T(reg) precursors. Lack of CXCR5(+) T(reg) cells leads to greater germinal center reactions. These results unveil a Bcl6-CXCR5 axis in T(reg) cells that undermines the development of follicular regulatory T (Tfr) cells that function to inhibit the germinal center reaction.
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spelling pubmed-31513402012-02-01 Follicular regulatory T (Tfr) cells with dual Foxp3 and Bcl6 expression suppress germinal center reactions Chung, Yeonseok Tanaka, Shinya Chu, Fuliang Nurieva, Roza Martinez, Gustavo J. Rawal, Seema Wang, Yi-Hong Lim, Ho Yong Reynolds, Joseph M. Zhou, Xiao-hui Fan, Hui-min Liu, Zhong-ming Neelapu, Sattva S. Dong, Chen Nat Med Article Foxp3(+) regulatory T (T(reg)) cells suppress different types of immune responses to help maintain homeostasis in the body. How T(reg) cells regulate humoral immunity, including germinal center reactions, is unclear. Here we identify a subset of T(reg) cells expressing CXCR5 and Bcl6, and localized in the germinal centers in mouse as well as human. The expression of CXCR5 on T(reg) cells depends on Bcl6. These CXCR5(+)Bcl6(+) T(reg) cells are absent in thymus but can be de novo generated from CXCR5(-)Foxp3(+) natural T(reg) precursors. Lack of CXCR5(+) T(reg) cells leads to greater germinal center reactions. These results unveil a Bcl6-CXCR5 axis in T(reg) cells that undermines the development of follicular regulatory T (Tfr) cells that function to inhibit the germinal center reaction. 2011-07-24 /pmc/articles/PMC3151340/ /pubmed/21785430 http://dx.doi.org/10.1038/nm.2426 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Chung, Yeonseok
Tanaka, Shinya
Chu, Fuliang
Nurieva, Roza
Martinez, Gustavo J.
Rawal, Seema
Wang, Yi-Hong
Lim, Ho Yong
Reynolds, Joseph M.
Zhou, Xiao-hui
Fan, Hui-min
Liu, Zhong-ming
Neelapu, Sattva S.
Dong, Chen
Follicular regulatory T (Tfr) cells with dual Foxp3 and Bcl6 expression suppress germinal center reactions
title Follicular regulatory T (Tfr) cells with dual Foxp3 and Bcl6 expression suppress germinal center reactions
title_full Follicular regulatory T (Tfr) cells with dual Foxp3 and Bcl6 expression suppress germinal center reactions
title_fullStr Follicular regulatory T (Tfr) cells with dual Foxp3 and Bcl6 expression suppress germinal center reactions
title_full_unstemmed Follicular regulatory T (Tfr) cells with dual Foxp3 and Bcl6 expression suppress germinal center reactions
title_short Follicular regulatory T (Tfr) cells with dual Foxp3 and Bcl6 expression suppress germinal center reactions
title_sort follicular regulatory t (tfr) cells with dual foxp3 and bcl6 expression suppress germinal center reactions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151340/
https://www.ncbi.nlm.nih.gov/pubmed/21785430
http://dx.doi.org/10.1038/nm.2426
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