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High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing
Human cells are constantly exposed to environmental and endogenous agents which can induce damage to DNA. Understanding the implications of these DNA modifications in the etiology of human diseases requires the examination about how these DNA lesions block DNA replication and induce mutations in cel...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152323/ https://www.ncbi.nlm.nih.gov/pubmed/21470959 http://dx.doi.org/10.1093/nar/gkr159 |