Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A

Abnormal alternative splicing of tau exon 10 results in imbalance of 3R-tau and 4R-tau expression, which is sufficient to cause neurofibrillary degeneration. Splicing factor SC35, a member of the superfamily of the serine/arginine-rich (SR) proteins, promotes tau exon 10 inclusion. The molecular mec...

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Detalles Bibliográficos
Autores principales: Qian, Wei, Liang, Hongwei, Shi, Jianhua, Jin, Nana, Grundke-Iqbal, Inge, Iqbal, Khalid, Gong, Cheng-Xin, Liu, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152345/
https://www.ncbi.nlm.nih.gov/pubmed/21470964
http://dx.doi.org/10.1093/nar/gkr195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152345/
https://www.ncbi.nlm.nih.gov/pubmed/21470964
http://dx.doi.org/10.1093/nar/gkr195

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