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Predicting Transcriptional Activity of Multiple Site p53 Mutants Based on Hybrid Properties
As an important tumor suppressor protein, reactivate mutated p53 was found in many kinds of human cancers and that restoring active p53 would lead to tumor regression. In this work, we developed a new computational method to predict the transcriptional activity for one-, two-, three- and four-site p...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152557/ https://www.ncbi.nlm.nih.gov/pubmed/21857971 http://dx.doi.org/10.1371/journal.pone.0022940 |