Low doses of the novel caspase-inhibitor GS-9450 leads to lower caspase-3 and -8 expression on peripheral CD4+ and CD8+ T-cells

Chronic hepatitis C virus (HCV) infection is characterized by increased rates of apoptotic hepatocytes and activated caspases have been shown in HCV-infected patients. GS-9450, a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models. This study evalua...

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Detalles Bibliográficos
Autores principales: Arends, J. E., Hoepelman, A. I. M., Nanlohy, N. M., Höppener, F. J. P., Hirsch, K. R., Park, J. G., van Baarle, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152720/
https://www.ncbi.nlm.nih.gov/pubmed/21667042
http://dx.doi.org/10.1007/s10495-011-0620-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152720/
https://www.ncbi.nlm.nih.gov/pubmed/21667042
http://dx.doi.org/10.1007/s10495-011-0620-2

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