GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke

The mood stabilizer lithium inhibits glycogen synthase kinase-3 (GSK-3) directly or indirectly by enhancing serine phosphorylation of both α and β isoforms. Lithium robustly protected primary brain neurons from glutamate-induced excitotoxicity; these actions were mimicked by other GSK-3 inhibitors o...

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Detalles Bibliográficos
Autores principales: Chuang, De-Maw, Wang, Zhifei, Chiu, Chi-Tso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152742/
https://www.ncbi.nlm.nih.gov/pubmed/21886605
http://dx.doi.org/10.3389/fnmol.2011.00015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152742/
https://www.ncbi.nlm.nih.gov/pubmed/21886605
http://dx.doi.org/10.3389/fnmol.2011.00015

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