Eosinophilic Colitis: University of Minnesota Experience and Literature Review

Eosinophilic colitis is a rare form of primary eosinophilic gastrointestinal disease that is poorly understood. Neonates and young adults are more frequently affected. Clinical presentation is highly variable depending on the depth of inflammatory response (mucosal, transmural, or serosal). The path...

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Autores principales: Gaertner, Wolfgang B., MacDonald, Jennifer E., Kwaan, Mary R., Shepela, Christopher, Madoff, Robert, Jessurun, Jose, Melton, Genevieve B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152953/
https://www.ncbi.nlm.nih.gov/pubmed/21837236
http://dx.doi.org/10.1155/2011/857508
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author Gaertner, Wolfgang B.
MacDonald, Jennifer E.
Kwaan, Mary R.
Shepela, Christopher
Madoff, Robert
Jessurun, Jose
Melton, Genevieve B.
author_facet Gaertner, Wolfgang B.
MacDonald, Jennifer E.
Kwaan, Mary R.
Shepela, Christopher
Madoff, Robert
Jessurun, Jose
Melton, Genevieve B.
author_sort Gaertner, Wolfgang B.
collection PubMed
description Eosinophilic colitis is a rare form of primary eosinophilic gastrointestinal disease that is poorly understood. Neonates and young adults are more frequently affected. Clinical presentation is highly variable depending on the depth of inflammatory response (mucosal, transmural, or serosal). The pathophysiology of eosinophilic colitis is unclear but is suspected to be related to a hypersensitivity reaction given its correlation with other atopic disorders and clinical response to corticosteroid therapy. Diagnosis is that of exclusion and differential diagnoses are many because colonic tissue eosinophilia may occur with other colitides (parasitic, drug-induced, inflammatory bowel disease, and various connective tissue disorders). Similar to other eosinophilic gastrointestinal disorders, steroid-based therapy and diet modification achieve very good and durable responses. In this paper, we present our experience with this rare pathology. Five patients (3 pediatric and 2 adults) presented with diarrhea and hematochezia. Mean age at presentation was 26 years. Mean duration of symptoms before pathologic diagnosis was 8 months. Mean eosinophil count per patient was 31 per high-power field. The pediatric patients responded very well to dietary modifications, with no recurrences. The adult patients were treated with steroids and did not respond. Overall mean followup was 22 (range, 2–48) months.
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spelling pubmed-31529532011-08-11 Eosinophilic Colitis: University of Minnesota Experience and Literature Review Gaertner, Wolfgang B. MacDonald, Jennifer E. Kwaan, Mary R. Shepela, Christopher Madoff, Robert Jessurun, Jose Melton, Genevieve B. Gastroenterol Res Pract Review Article Eosinophilic colitis is a rare form of primary eosinophilic gastrointestinal disease that is poorly understood. Neonates and young adults are more frequently affected. Clinical presentation is highly variable depending on the depth of inflammatory response (mucosal, transmural, or serosal). The pathophysiology of eosinophilic colitis is unclear but is suspected to be related to a hypersensitivity reaction given its correlation with other atopic disorders and clinical response to corticosteroid therapy. Diagnosis is that of exclusion and differential diagnoses are many because colonic tissue eosinophilia may occur with other colitides (parasitic, drug-induced, inflammatory bowel disease, and various connective tissue disorders). Similar to other eosinophilic gastrointestinal disorders, steroid-based therapy and diet modification achieve very good and durable responses. In this paper, we present our experience with this rare pathology. Five patients (3 pediatric and 2 adults) presented with diarrhea and hematochezia. Mean age at presentation was 26 years. Mean duration of symptoms before pathologic diagnosis was 8 months. Mean eosinophil count per patient was 31 per high-power field. The pediatric patients responded very well to dietary modifications, with no recurrences. The adult patients were treated with steroids and did not respond. Overall mean followup was 22 (range, 2–48) months. Hindawi Publishing Corporation 2011 2011-07-10 /pmc/articles/PMC3152953/ /pubmed/21837236 http://dx.doi.org/10.1155/2011/857508 Text en Copyright © 2011 Wolfgang B. Gaertner et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gaertner, Wolfgang B.
MacDonald, Jennifer E.
Kwaan, Mary R.
Shepela, Christopher
Madoff, Robert
Jessurun, Jose
Melton, Genevieve B.
Eosinophilic Colitis: University of Minnesota Experience and Literature Review
title Eosinophilic Colitis: University of Minnesota Experience and Literature Review
title_full Eosinophilic Colitis: University of Minnesota Experience and Literature Review
title_fullStr Eosinophilic Colitis: University of Minnesota Experience and Literature Review
title_full_unstemmed Eosinophilic Colitis: University of Minnesota Experience and Literature Review
title_short Eosinophilic Colitis: University of Minnesota Experience and Literature Review
title_sort eosinophilic colitis: university of minnesota experience and literature review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152953/
https://www.ncbi.nlm.nih.gov/pubmed/21837236
http://dx.doi.org/10.1155/2011/857508
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