Verotoxin-1 Treatment or Manipulation of its Receptor Globotriaosylceramide (Gb3) for Reversal of Multidrug Resistance to Cancer Chemotherapy

A major problem with anti-cancer drug treatment is the development of acquired multidrug resistance (MDR) of the tumor cells. Verotoxin-1 (VT-1) exerts its cytotoxicity by targeting the globotriaosylceramide membrane receptor (Gb3), a glycolipid associated with multidrug resistance. Gb3 is overexpre...

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Detalles Bibliográficos
Autores principales: Behnam-Motlagh, Parviz, Tyler, Andreas, Grankvist, Kjell, Johansson, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153170/
https://www.ncbi.nlm.nih.gov/pubmed/22069561
http://dx.doi.org/10.3390/toxins2102467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153170/
https://www.ncbi.nlm.nih.gov/pubmed/22069561
http://dx.doi.org/10.3390/toxins2102467

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