The Zinc-Dependent Protease Activity of the Botulinum Neurotoxins

The botulinum neurotoxins (BoNT, serotypes A-G) are some of the most toxic proteins known and are the causative agents of botulism. Following exposure, the neurotoxin binds and enters peripheral cholinergic nerve endings and specifically and selectively cleaves one or more SNARE proteins to produce...

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Autores principales: Lebeda, Frank J., Cer, Regina Z., Mudunuri, Uma, Stephens, Robert, Singh, Bal Ram, Adler, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153231/
https://www.ncbi.nlm.nih.gov/pubmed/22069621
http://dx.doi.org/10.3390/toxins2050978
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author Lebeda, Frank J.
Cer, Regina Z.
Mudunuri, Uma
Stephens, Robert
Singh, Bal Ram
Adler, Michael
author_facet Lebeda, Frank J.
Cer, Regina Z.
Mudunuri, Uma
Stephens, Robert
Singh, Bal Ram
Adler, Michael
author_sort Lebeda, Frank J.
collection PubMed
description The botulinum neurotoxins (BoNT, serotypes A-G) are some of the most toxic proteins known and are the causative agents of botulism. Following exposure, the neurotoxin binds and enters peripheral cholinergic nerve endings and specifically and selectively cleaves one or more SNARE proteins to produce flaccid paralysis. This review centers on the kinetics of the Zn-dependent proteolytic activities of these neurotoxins, and briefly describes inhibitors, activators and factors underlying persistence of toxin action. Some of the structural, enzymatic and inhibitor data that are discussed here are available at the botulinum neurotoxin resource, BotDB (http://botdb.abcc.ncifcrf.gov).
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spelling pubmed-31532312011-11-08 The Zinc-Dependent Protease Activity of the Botulinum Neurotoxins Lebeda, Frank J. Cer, Regina Z. Mudunuri, Uma Stephens, Robert Singh, Bal Ram Adler, Michael Toxins (Basel) Review The botulinum neurotoxins (BoNT, serotypes A-G) are some of the most toxic proteins known and are the causative agents of botulism. Following exposure, the neurotoxin binds and enters peripheral cholinergic nerve endings and specifically and selectively cleaves one or more SNARE proteins to produce flaccid paralysis. This review centers on the kinetics of the Zn-dependent proteolytic activities of these neurotoxins, and briefly describes inhibitors, activators and factors underlying persistence of toxin action. Some of the structural, enzymatic and inhibitor data that are discussed here are available at the botulinum neurotoxin resource, BotDB (http://botdb.abcc.ncifcrf.gov). MDPI 2010-05-07 /pmc/articles/PMC3153231/ /pubmed/22069621 http://dx.doi.org/10.3390/toxins2050978 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Lebeda, Frank J.
Cer, Regina Z.
Mudunuri, Uma
Stephens, Robert
Singh, Bal Ram
Adler, Michael
The Zinc-Dependent Protease Activity of the Botulinum Neurotoxins
title The Zinc-Dependent Protease Activity of the Botulinum Neurotoxins
title_full The Zinc-Dependent Protease Activity of the Botulinum Neurotoxins
title_fullStr The Zinc-Dependent Protease Activity of the Botulinum Neurotoxins
title_full_unstemmed The Zinc-Dependent Protease Activity of the Botulinum Neurotoxins
title_short The Zinc-Dependent Protease Activity of the Botulinum Neurotoxins
title_sort zinc-dependent protease activity of the botulinum neurotoxins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153231/
https://www.ncbi.nlm.nih.gov/pubmed/22069621
http://dx.doi.org/10.3390/toxins2050978
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