SLT-VEGF Reduces Lung Metastases, Decreases Tumor Recurrence, and Improves Survival in an Orthotopic Melanoma Model

SLT-VEGF is a recombinant cytotoxin comprised of Shiga-like toxin (SLT) subunit A fused to human vascular endothelial growth factor (VEGF). It is highly cytotoxic to tumor endothelial cells overexpressing VEGF receptor-2 (VEGFR-2/KDR/Flk1) and inhibits the growth of primary tumors in subcutaneous mo...

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Detalles Bibliográficos
Autores principales: Ackerman, Rachel, Backer, Joseph M., Backer, Marina, Skariah, Sini, Hamby, Carl V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153293/
https://www.ncbi.nlm.nih.gov/pubmed/22069683
http://dx.doi.org/10.3390/toxins2092242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153293/
https://www.ncbi.nlm.nih.gov/pubmed/22069683
http://dx.doi.org/10.3390/toxins2092242

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