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Structure-based drug design of a new chemical class of small molecules active against influenza A nucleoprotein in vitro and in vivo
We report preliminary results and a summary of a bottom-up approach to identify new, active, nontoxic, small-molecule antivirals designed to have а novel mechanism of action. We employed the procedure to identify 3-mercapto-1,2,4-triazoles derivatives as potential NP inhibitors in silico and subsequ...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153361/ https://www.ncbi.nlm.nih.gov/pubmed/21894258 http://dx.doi.org/10.1371/currents.RRN1253 |