A Crystal Structure of the Catalytic Core Domain of an Avian Sarcoma and Leukemia Virus Integrase Suggests an Alternate Dimeric Assembly

Integrase (IN) is an important therapeutic target in the search for anti-Human Immunodeficiency Virus (HIV) inhibitors. This enzyme is composed of three domains and is hard to crystallize in its full form. First structural results on IN were obtained on the catalytic core domain (CCD) of the avian R...

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Detalles Bibliográficos
Autores principales: Ballandras, Allison, Moreau, Karen, Robert, Xavier, Confort, Marie-Pierre, Merceron, Romain, Haser, Richard, Ronfort, Corinne, Gouet, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153463/
https://www.ncbi.nlm.nih.gov/pubmed/21857987
http://dx.doi.org/10.1371/journal.pone.0023032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153463/
https://www.ncbi.nlm.nih.gov/pubmed/21857987
http://dx.doi.org/10.1371/journal.pone.0023032

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