Cargando…

A Crystal Structure of the Catalytic Core Domain of an Avian Sarcoma and Leukemia Virus Integrase Suggests an Alternate Dimeric Assembly

Integrase (IN) is an important therapeutic target in the search for anti-Human Immunodeficiency Virus (HIV) inhibitors. This enzyme is composed of three domains and is hard to crystallize in its full form. First structural results on IN were obtained on the catalytic core domain (CCD) of the avian R...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ballandras, Allison, Moreau, Karen, Robert, Xavier, Confort, Marie-Pierre, Merceron, Romain, Haser, Richard, Ronfort, Corinne, Gouet, Patrice
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153463/ https://www.ncbi.nlm.nih.gov/pubmed/21857987 http://dx.doi.org/10.1371/journal.pone.0023032

Ejemplares similares

Biochemical Characterization of Novel Retroviral Integrase Proteins
por: Ballandras-Colas, Allison, et al.
Publicado: (2013)

Nuclear import of Avian Sarcoma Virus integrase is facilitated by host cell factors
por: Andrake, Mark D, et al.
Publicado: (2008)

The C-Terminal Domain of HIV-1 Integrase: A Swiss Army Knife for the Virus?
por: Rocchi, Cecilia, et al.
Publicado: (2022)

Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase
por: Zheng, Yingfeng, et al.
Publicado: (2010)

A Possible Role for the Asymmetric C-Terminal Domain Dimer of Rous Sarcoma Virus Integrase in Viral DNA Binding
por: Shi, Ke, et al.
Publicado: (2013)

Cryo-EM reveals a novel octameric integrase structure for β-retroviral intasome function
por: Ballandras-Colas, Allison, et al.
Publicado: (2016)

An Unusual Helix Turn Helix Motif in the Catalytic Core of HIV-1 Integrase Binds Viral DNA and LEDGF
por: Merad, Hayate, et al.
Publicado: (2009)

Non-Cryogenic Structure and Dynamics of HIV-1 Integrase Catalytic Core Domain by X-ray Free-Electron Lasers
por: Park, Jae-Hyun, et al.
Publicado: (2019)

Crosslinking and mass spectrometry suggest that the isolated NTD domain dimer of Moloney murine leukemia virus integrase adopts a parallel arrangement in solution
por: Henriquez, Daniel R, et al.
Publicado: (2013)

Multivalent interactions essential for lentiviral integrase function
por: Ballandras-Colas, Allison, et al.
Publicado: (2022)

The HIV-1 Integrase C-Terminal Domain Induces TAR RNA Structural Changes Promoting Tat Binding
por: Rocchi, Cecilia, et al.
Publicado: (2022)

Persistent production of an integrase-deleted HIV-1 variant with no resistance mutation and wild-type proviral DNA in a treated patient
por: Trabaud, MA, et al.
Publicado: (2014)

Special Issue “Viral and Host Factors Driving the Emergence and the Evolution of the SARS-CoV-2 and Other Coronaviruses”
por: Ronfort, Corinne
Publicado: (2022)

Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication
por: Xu, Zaikun, et al.
Publicado: (2008)

Non-Catalytic Site HIV-1 Integrase Inhibitors Disrupt Core Maturation and Induce a Reverse Transcription Block in Target Cells
por: Balakrishnan, Mini, et al.
Publicado: (2013)

Human H4 tail stimulates HIV-1 integration through binding to the carboxy-terminal domain of integrase
por: Mauro, Eric, et al.
Publicado: (2019)

A Symmetric Region of the HIV-1 Integrase Dimerization Interface Is Essential for Viral Replication
por: Serrao, Erik, et al.
Publicado: (2012)

Relative Comparison of Catalytic Characteristics of Human Foamy Virus and HIV-1 Integrases
por: Knyazhanskaya, E. S., et al.
Publicado: (2009)

Study on suitable analysis method for HIV-1 non-catalytic integrase inhibitor
por: Park, Ki Hoon, et al.
Publicado: (2021)

Dialysis Purification of Integrase-DNA Complexes Provides High-Resolution Atomic Force Microscopy Images: Dimeric Recombinant HIV-1 Integrase Binding and Specific Looping on DNA
por: Tsuruyama, Tatsuaki, et al.
Publicado: (2013)

Catalytic Site Cooperativity in Dimeric Methylthioadenosine Nucleosidase
por: Wang, Shanzhi, et al.
Publicado: (2014)

Design of inhibitors of the HIV-1 integrase core domain using virtual screening
por: Regon, Preetom, et al.
Publicado: (2014)

The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2
por: Swuec, Paolo, et al.
Publicado: (2016)

Integrase and integration: biochemical activities of HIV-1 integrase
por: Delelis, Olivier, et al.
Publicado: (2008)

HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges
por: Mukundan, Vineeth Thachappilly, et al.
Publicado: (2011)

Whole genome sequence analysis of Australian avian pathogenic Escherichia coli that carry the class 1 integrase gene
por: Cummins, Max L., et al.
Publicado: (2019)

Pair Interaction of Catalytical Sphere Dimers in Chemically Active Media
por: Shi, Jing-Min, et al.
Publicado: (2018)

Di‐tert‐butyldiphosphatetrahedrane: Catalytic Synthesis of the Elusive Phosphaalkyne Dimer
por: Hierlmeier, Gabriele, et al.
Publicado: (2019)

Resistance to Integrase Inhibitors
por: Métifiot, Mathieu, et al.
Publicado: (2010)

A novel assay for screening inhibitors targeting HIV-1 integrase dimerization based on Ni-NTA magnetic agarose beads
por: Zhang, Dawei, et al.
Publicado: (2016)

Relationship between HIV integrase polymorphisms and integrase inhibitor susceptibility: An in silico analysis
por: Hutapea, Hotma Martogi Lorensi, et al.
Publicado: (2018)

Hepatitis B virus core protein dimer-dimer interface is critical for viral replication
por: Zheng, Chang-Long, et al.
Publicado: (2019)

Deciphering key features in protein structures with the new ENDscript server
por: Robert, Xavier, et al.
Publicado: (2014)

The bacteriophage lambda integrase catalytic domain can be modified to act with the regulatory domain as a recombination-competent binary recombinase
por: Williams, Joe D., et al.
Publicado: (2022)

Structure of the catalytic core of the Integrator complex
por: Pfleiderer, Moritz M., et al.
Publicado: (2021)

HIV-2 Integrase Variation in Integrase Inhibitor-Naïve Adults in Senegal, West Africa
por: Gottlieb, Geoffrey S., et al.
Publicado: (2011)

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
por: Koneru, Pratibha C, et al.
Publicado: (2019)

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis
por: Elliott, Jennifer L, et al.
Publicado: (2020)

Prototype Foamy Virus Integrase Displays Unique Biochemical Activities among Retroviral Integrases
por: Rabe, Anthony J., et al.
Publicado: (2021)

Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation
por: Vercellino, Irene, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_chfovnmk4qan631set10olvsjv