Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes

The mammalian heart loses its regenerative potential soon after birth. Adult cardiac myocytes (ACMs) permanently exit the cell cycle, and E2F-dependent genes are stably silenced, although the underlying mechanism is unclear. Heterochromatin, which silences genes in many biological contexts, accumula...

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Detalles Bibliográficos
Autores principales: Sdek, Patima, Zhao, Peng, Wang, Yaping, Huang, Chang-jiang, Ko, Christopher Y., Butler, Peter C., Weiss, James N., MacLellan, W. Robb
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153646/
https://www.ncbi.nlm.nih.gov/pubmed/21825075
http://dx.doi.org/10.1083/jcb.201012049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153646/
https://www.ncbi.nlm.nih.gov/pubmed/21825075
http://dx.doi.org/10.1083/jcb.201012049

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