Local Low-Dose Lovastatin Delivery Improves the Bone-Healing Defect Caused by Nf1 Loss of Function in Osteoblasts

Postfracture tibial nonunion (pseudoarthrosis) leads to lifelong disability in patients with neurofibromatosis type I (NF1), a disorder caused by mutations in the NF1 gene. To determine the contribution of NF1 in bone healing, we assessed bone healing in the [Image: see text] conditional mouse model...

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Detalles Bibliográficos
Autores principales: Wang, Weixi, Nyman, Jeffry S, Moss, Heather E, Gutierrez, Gloria, Mundy, Gregory R, Yang, Xiangli, Elefteriou, Florent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154004/
https://www.ncbi.nlm.nih.gov/pubmed/20200958
http://dx.doi.org/10.1002/jbmr.42

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154004/
https://www.ncbi.nlm.nih.gov/pubmed/20200958
http://dx.doi.org/10.1002/jbmr.42

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