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Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes
Elucidation of natural product biosynthetic pathways provides important insights about the assembly of potent bioactive molecules, and expands access to unique enzymes able to selectively modify complex substrates. Here we show full reconstitution in vitro of an unusual multi-step oxidative cascade...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154026/ https://www.ncbi.nlm.nih.gov/pubmed/21778983 http://dx.doi.org/10.1038/nchem.1087 |