Site-specific modification of ED-B-targeting antibody using intein-fusion technology

BACKGROUND: A promising new approach in cancer therapy is the use of tumor specific antibodies coupled to cytotoxic agents. Currently these immunoconjugates are prepared by rather unspecific coupling chemistries, resulting in heterogeneous products. As the drug load is a key parameter for the antitu...

Descripción completa

Detalles Bibliográficos
Autores principales: Möhlmann, Sina, Bringmann, Peter, Greven, Simone, Harrenga, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154154/
https://www.ncbi.nlm.nih.gov/pubmed/21777442
http://dx.doi.org/10.1186/1472-6750-11-76

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154154/
https://www.ncbi.nlm.nih.gov/pubmed/21777442
http://dx.doi.org/10.1186/1472-6750-11-76

Ejemplares similares