EGF Receptor Exposed to Oxidative Stress Acquires Abnormal Phosphorylation and Aberrant Activated Conformation That Impairs Canonical Dimerization

Crystallographic studies have offered understanding of how receptor tyrosine kinases from the ErbB family are regulated by their growth factor ligands. A conformational change of the EGFR (ErbB1) was shown to occur upon ligand binding, where a solely ligand-mediated mode of dimerization/activation w...

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Detalles Bibliográficos
Autores principales: Filosto, Simone, Khan, Elaine M., Tognon, Emiliana, Becker, Cathleen, Ashfaq, Majid, Ravid, Tommer, Goldkorn, Tzipora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154401/
https://www.ncbi.nlm.nih.gov/pubmed/21853092
http://dx.doi.org/10.1371/journal.pone.0023240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154401/
https://www.ncbi.nlm.nih.gov/pubmed/21853092
http://dx.doi.org/10.1371/journal.pone.0023240

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