Down-modulation of cancer targets using locked nucleic acid (LNA)-based antisense oligonucleotides without transfection

Usually, small interfering RNAs and most antisense molecules need mechanical or chemical delivery methods to down-modulate the targeted mRNA. However, these delivery approaches complicate the interpretations of biological consequences. We show that locked nucleic acid (LNA)-based antisense oligonucl...

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Detalles Bibliográficos
Autores principales: Zhang, Y, Qu, Z, Kim, S, Shi, V, Liao, B, Kraft, P, Bandaru, R, Wu, Y, Greenberger, L M, Horak, I D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Enabling Technologies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154478/
https://www.ncbi.nlm.nih.gov/pubmed/21179173
http://dx.doi.org/10.1038/gt.2010.133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154478/
https://www.ncbi.nlm.nih.gov/pubmed/21179173
http://dx.doi.org/10.1038/gt.2010.133

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