Bypass of Aflatoxin B(1) Adducts by the Sulfolobus solfataricus DNA Polymerase IV

[Image: see text] Aflatoxin B(1) (AFB(1)) is oxidized to an epoxide in vivo, which forms an N7-dG DNA adduct (AFB(1)–N7-dG). The AFB(1)–N7-dG can rearrange to a formamidopyrimidine (AFB(1)–FAPY) derivative. Both AFB(1)–N7-dG and the β-anomer of the AFB(1)–FAPY adduct yield G→T transversions in Esche...

Descripción completa

Detalles Bibliográficos
Autores principales: Banerjee, Surajit, Brown, Kyle L., Egli, Martin, Stone, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154525/
https://www.ncbi.nlm.nih.gov/pubmed/21790157
http://dx.doi.org/10.1021/ja2015668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154525/
https://www.ncbi.nlm.nih.gov/pubmed/21790157
http://dx.doi.org/10.1021/ja2015668

Ejemplares similares