Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1

The mediator protein Claspin is critical for the activation of the checkpoint kinase Chk1 during checkpoint responses to stalled replication forks. This function involves the Chk1-activating domain (CKAD) of Claspin, which undergoes phosphorylation on multiple conserved sites. These phosphorylations...

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Detalles Bibliográficos
Autores principales: Meng, Zheng, Capalbo, Luisa, Glover, David M., Dunphy, William G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154880/
https://www.ncbi.nlm.nih.gov/pubmed/21680713
http://dx.doi.org/10.1091/mbc.E11-01-0048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154880/
https://www.ncbi.nlm.nih.gov/pubmed/21680713
http://dx.doi.org/10.1091/mbc.E11-01-0048

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