Frequent Alteration of MLL3 Frameshift Mutations in Microsatellite Deficient Colorectal Cancer

BACKGROUND: MLL3 is a histone 3- lysine 4 methyltransferase with tumor-suppressor properties that belongs to a family of chromatin regulator genes potentially altered in neoplasia. Mutations in MLL3 were found in a whole genome analysis of colorectal cancer but have not been confirmed by a separate...

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Detalles Bibliográficos
Autores principales: Watanabe, Yoshiyuki, Castoro, Ryan J., Kim, Hyun Soo, North, Brittany, Oikawa, Ritsuko, Hiraishi, Tetsuya, Ahmed, Saira S., Chung, Woonbok, Cho, Mee-Yon, Toyota, Minoru, Itoh, Fumio, Estecio, Marcos R. H., Shen, Lanlan, Jelinek, Jaroslav, Issa, Jean-Pierre J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154922/
https://www.ncbi.nlm.nih.gov/pubmed/21853109
http://dx.doi.org/10.1371/journal.pone.0023320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154922/
https://www.ncbi.nlm.nih.gov/pubmed/21853109
http://dx.doi.org/10.1371/journal.pone.0023320

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