In Vivo Elimination of MHC-I-Deficient Lymphocytes by Activated Natural Killer Cells Is Independent of Granzymes A and B

NK cells kill target cells mainly via exocytosis of granules containing perforin (perf) and granzymes (gzm). In vitro, gzm delivery into the target cell cytosol results in apoptosis, and induction of apoptosis is severely impaired in the absence of gzm A and B. However, their importance for in vivo...

Descripción completa

Detalles Bibliográficos
Autores principales: Regner, Matthias, Pavlinovic, Lisa, Young, Nicolie, Müllbacher, Arno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154924/
https://www.ncbi.nlm.nih.gov/pubmed/21853094
http://dx.doi.org/10.1371/journal.pone.0023252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154924/
https://www.ncbi.nlm.nih.gov/pubmed/21853094
http://dx.doi.org/10.1371/journal.pone.0023252

Ejemplares similares