Cargando…
In Vivo Elimination of MHC-I-Deficient Lymphocytes by Activated Natural Killer Cells Is Independent of Granzymes A and B
NK cells kill target cells mainly via exocytosis of granules containing perforin (perf) and granzymes (gzm). In vitro, gzm delivery into the target cell cytosol results in apoptosis, and induction of apoptosis is severely impaired in the absence of gzm A and B. However, their importance for in vivo...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154924/ https://www.ncbi.nlm.nih.gov/pubmed/21853094 http://dx.doi.org/10.1371/journal.pone.0023252 |