The Nucleotide Exchange Factor Ric-8A Is a Chaperone for the Conformationally Dynamic Nucleotide-Free State of Gαi1

Heterotrimeric G protein α subunits are activated upon exchange of GDP for GTP at the nucleotide binding site of Gα, catalyzed by guanine nucleotide exchange factors (GEFs). In addition to transmembrane G protein-coupled receptors (GPCRs), which act on G protein heterotrimers, members of the family...

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Detalles Bibliográficos
Autores principales: Thomas, Celestine J., Briknarová, Klára, Hilmer, Jonathan K., Movahed, Navid, Bothner, Brian, Sumida, John P., Tall, Gregory G., Sprang, Stephen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154933/
https://www.ncbi.nlm.nih.gov/pubmed/21853086
http://dx.doi.org/10.1371/journal.pone.0023197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154933/
https://www.ncbi.nlm.nih.gov/pubmed/21853086
http://dx.doi.org/10.1371/journal.pone.0023197

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